Cancer cachexia is defined by an ongoing loss of skeletal muscle mass
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چکیده
منابع مشابه
Skeletal muscle loss: cachexia, sarcopenia, and inactivity.
Loss of skeletal muscle mass occurs during aging (sarcopenia), disease (cachexia), or inactivity (atrophy). This article contrasts and compares the metabolic causes of loss of muscle resulting from these conditions. An understanding of the underlying causes of muscle loss is critical for the development of strategies and therapies to preserve muscle mass and function. Loss of skeletal muscle pr...
متن کاملNew genetic signatures associated with cancer cachexia as defined by low skeletal muscle index and weight loss
BACKGROUND Cachexia affects the majority with advanced cancer. Based on current demographic and clinical factors, it is not possible to predict who will develop cachexia or not. Such variation may, in part, be due to genotype. It has recently been proposed to extend the diagnostic criteria for cachexia to include a direct measure of low skeletal muscle index (LSMI) in addition to weight loss (W...
متن کاملAltered expression of skeletal muscle myosin isoforms in cancer cachexia.
Cachexia is commonly seen in cancer and is characterized by severe muscle wasting, but little is known about the effect of cancer cachexia on expression of contractile protein isoforms such as myosin. Other causes of muscle atrophy shift expression of myosin isoforms toward increased fast (type II) isoform expression. We injected mice with murine C-26 adenocarcinoma cells, a tumor cell line tha...
متن کاملSkeletal muscle mitochondrial uncoupling in a murine cancer cachexia model.
Approximately half of all cancer patients present with cachexia, a condition in which disease-associated metabolic changes lead to a severe loss of skeletal muscle mass. Working toward an integrated and mechanistic view of cancer cachexia, we investigated the hypothesis that cancer promotes mitochondrial uncoupling in skeletal muscle. We subjected mice to in vivo phosphorous-31 nuclear magnetic...
متن کاملCancer cachexia-anorexia syndrome and skeletal muscle wasting
Background. Cachexia-anorexia syndrome is a common and important indicator of cancer. It occurs in 30% to 80% of cancer patients. Cachexia means “bad condition” and may be present in the early stages of tumor growth, before any signs of malignancy. Cancer cachexia is a syndrome of progressive body wasting, characterized by loss of adipose tissue and skeletal muscle mass. In most cancer patients...
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ژورنال
عنوان ژورنال: Annals of Palliative Medicine
سال: 2019
ISSN: 2224-5820,2224-5839
DOI: 10.21037/apm.2018.12.01